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HBT1

CAT: 0013-GTR19156677-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156677-01Size:200 mg
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Description
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. The mode of HBT1 and LY451395 binding to a pocket in the LBD of AMPA-R differed: HBT1, formed hydrogen bonds with S518 in the LBD. Lower agonistic profile of HBT1 may associate with its lower risks of bell-shaped responses in BDNF production in primary neurons.
CAS Number
489408-02-8
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (647.01 mM)
Smiles
Cc1cc (nn1CC (=O) Nc1sc2CCCCc2c1C (N) =O) C (F) (F) F
Molecular Formula
C16H17F3N4O2S
Molecular Weight
386.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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