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Chebulinic acid

CAT: 0013-GTR19156664-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156664-01Size:1 g
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Description
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.Chebulinic acid obviously inhibited HQ/Cu (II) - and H (2) O (2) /Cu (II) -mediated pBR322 DNA strand breaks. When MRC-5 cells were treated with HQ/Cu (II), the presence of Chebulinic acid inhibited HQ/Cu (II) -mediated double-strand breaks of genomic DNA [1].Chebulinic acid had no effect on KCl-induced aortic contraction, but irreversibly inhibited the contractile responses to phenylephrine in an apparently non-competitive manner. Chebulinic acid also inhibited contractile responses of rat aorta to 5-hydroxytryptamine and angiotensin II. 3. Chebulinic acid inhibited the binding of [3H]-prazosin to dog aortic microsomal membranes in a concentration-dependent manner with an IC50 value of 0.34 mmol/L.
CAS Number
18942-26-2
Purity
>98% (HPLC)
Solubility
DMSO:Soluble
Smiles
OC (C[C@H] (C (O[C@@] ([C@H] (O[C@H]1OC (C2=CC (O) =C (O) C (O) =C2) =O) COC (C3=CC (O) =C (O) C (O) =C3) =O) ([H]) [C@@] (OC (C4=CC (O) =C (O) C (O) =C4) =O) ([H]) [C@@]1 ([H]) OC5=O) =O) [C@@] ([C@H]6O) ([H]) C (C5=CC (O) =C7O) =C7OC6=O) =O
Molecular Formula
C41H28O27
Molecular Weight
956.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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