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Bisabolangelone

CAT: 0013-GTR19156647-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156647-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL) -12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. BISA inhibited DC functions by blocking MAPK and NF-κB signaling.
CAS Number
30557-81-4
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (402.71 mM)
Smiles
O=C1C=C (C) C[C@@]2 ([H]) [C@]1 ([H]) [C@@] (C) (O) /C (O2) =C/C=C (C) \C
Molecular Formula
C15H20O3
Molecular Weight
248.32
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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