Epimagnolin A

Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion. A herbal compound fargesin obtained from M. fargesii, has exerted anti-inflammatory effects in human monocytic THP-1 cells in the previous study. it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA) -induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Furthermore, it was investigated the modulating effects of epimagnolin A on mitogen-activated protein kinase, nuclear factor-kappa B (NF-κB), and activator protein 1 (AP-1) activities. Phosphorylation of p38 and nuclear translocation of p50 and c-Jun were down-regulated by epimagnolin A in the PMA-stimulated THP-1 cell. The results revealed that epimagnolin A attenuated the binding affinity of NF-κB and AP-1 transcription factors to IL-6 promoter and IL-6 production through p38/NF-kB and AP-1 signaling pathways in the PMA-stimulated THP-1 cells. These results suggest that epimagnolin A can be a useful drug for the treatment of inflammatory diseases.

41689-51-4

>98% (HPLC)

In Vitro: DMSO : 100 mg/mL (240.12 mM)

COC1=C (OC) C (OC) =CC ([C@H]2OC[C@]3 ([H]) [C@@H] (C4=CC=C (OC) C (OC) =C4) OC[C@@]32[H]) =C1

C23H28O7

416.46

Storage temperature: -20°C. Stability: ≥ 2 years