Products for Research Use Only
RegisterLogin

Resatorvid

CAT: 0013-GTR19156554-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19156554-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4) . Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 nM) .Resatorvid suppresses the production of NO, TNF-α, and IL-6 from LPS-stimulated human peripheral blood mononuclear cells (PBMCs, IC50s: 11-33 nM) . Resatorvid (1-100 nM; 15 minutes; PBMCs cells) markedly inhibits the LPS-induced phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2), p38, and JNK/SAPK as well as degradation of IκBβ at a concentration of 100 nM. Resatorvid (1-100 nM; 4 hours) inhibits mRNA expression of IL-6 and TNF-α induced by LPS and IFN-γ in RAW264.7 cells.In ApoE knockout and wild-type mice, Resatorvid (0.3 mg/kg; intraperitoneal injection; twice a week; for 4 weeks) treatment inhibits serum autoantibodies (ANA and anti-dsDNA), cytokines (IFN-γ, TNF-α, IL-1β), lung inflammation, and intima-media thickness in brachiocephalic artery.
CAS Number
243984-11-4
Product Name Alternative
TAK-242, CLI-095
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (276.38 mM; Need ultrasonic)
Smiles
O=S ([C@H]1C (C (OCC) =O) =CCCC1) (NC2=CC=C (C=C2Cl) F) =O
Molecular Formula
C15H17ClFNO4S
Molecular Weight
361.82
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
MBS3612777-01Resatorvid
A11543-100Resatorvid 100mg
A11543-50Resatorvid 50mg
A11543-5Resatorvid 5mg
A11543-25Resatorvid 25mg
A11543-2Resatorvid 2mg
A11543-1Resatorvid 1mg
A11543-10Resatorvid 10mg
S7455-25mgResatorvid (TAK-242)
MBS130179-01TAK-242(Resatorvid)

Popular Products