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SBI-477

CAT: 0013-GTR19157457-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157457-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes. SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4) . Depleting MondoA in myocytes reproduced the effects of SBI-477 on glucose uptake and myocyte lipid accumulation.
CAS Number
781628-99-7
Purity
>98% (HPLC)
Solubility
DMSO:65 mg/mL (134.43 mM; Need ultrasonic)
Smiles
O=C (NC1=NC (C2=CC=C (OC) C=C2) =CS1) C3=CC=C (OCC (N4CCOCC4) =O) C (OC) =C3
Molecular Formula
C24H25N3O6S
Molecular Weight
483.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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Alternative Products

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BUP08927-01SBI-477
HY-124417-01SBI-477 analog
A18962-50SBI-477 50mg
A18962-25SBI-477 25mg
A18962-5SBI-477 5mg
A18962-500SBI-477 500mg
A18962-1SBI-477 1mg
A18962-100SBI-477 100mg
A18962-10SBI-477 10mg
A18962-10mM-DSBI-477 10mM * 1mL in DMSO

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