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SC 58125

CAT: 0013-GTR19157102-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157102-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesicSC-58125 treatment on the growth of human colon carcinoma cells in nude mice. Delaying treatment by 2, 4, or 7 weeks following implantation of the carcinoma cells resulted in a significant inhibition of tumor growth. Furthermore, short-term (48 hours) treatment with SC-58125 was sufficient to attenuate tumor growth for up to 15 days. SC-58125 treatment did not alter the rate at which cells underwent apoptosis, but did result in a delayed progression through the cell cycle at the G (2) /M transition. Accordingly, p34 (cdc2) protein levels and activity were decreased following SC-58125 treatment.SC-58125 primarily exerts a cytostatic effect in vivo, which is likely to be mediated through inhibition of progression through the G (2) /M phase of the cell cycle.
CAS Number
162054-19-5
Purity
>98% (HPLC)
Solubility
DMSO:Soluble
Smiles
FC (C1=NN (C2=CC=C (S (=O) (C) =O) C=C2) C (C3=CC=C (F) C=C3) =C1) (F) F
Molecular Formula
C17H12F4N2O2S
Molecular Weight
384.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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Alternative Products

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B5347-50SC 58125
HY-W013164-01SC-58125
HY-W013164RSC-58125 (Standard)
A24314-5SC-58125 5mg
A24314-50SC-58125 50mg
A24314-100SC-58125 100mg
A24314-10SC-58125 10mg

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