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2',4'-DIHYDROXYCHALCONE

CAT: 0013-GTR19156968-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156968-01Size:200 mg
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Description
2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effectsIn the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked. The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC. The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced. The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin. Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90. 2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor.
CAS Number
1776-30-3
Product Name Alternative
2',4'-DHC
Purity
>98% (HPLC)
Smiles
O=C (C1=CC=C (O) C=C1O) C=CC2=CC=CC=C2
Molecular Formula
C15H12O3?
Molecular Weight
240.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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