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SR-3677

CAT: 0013-GTR19156474-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156474-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM) . (In Vitro) :SR-3677 has an IC50 of ~3 nM in enzyme and cell based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 nonkinase enzymes and receptors. The IC50 value of SR-3677 for ROCK-I is 56±12 nM. The hydrophobic interaction of the benzodioxane phenyl ring with the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR-3677. (In Vivo) : Pharmacology studies shows that SR-3677 is efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 μM SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70–80% for the 2–5 h time points.
CAS Number
1072959-67-1
Purity
>98% (HPLC)
Solubility
DMSO:40 mg/mL (97.93 mM)
Smiles
CN (C) CCOC1=C (NC (C2OC (C=CC=C3) =C3OC2) =O) C=CC (C4=CNN=C4) =C1
Molecular Formula
C22H24N4O4
Molecular Weight
408.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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