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Liarozole

CAT: 0013-GTR19156415-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156415-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Liarozole is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase) .Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders. (In Vitro) :Liarozole (0.01~10 μM; 9 days; MCF-7 cells) inhibits cells proliferation.Liarozole (1 μM; 4 days; mesenchymal cells) completely inhibits chondrogenesis. (In Vivo) :Liarozole (5-20 mg/kg; p.o.; 3 days) reverses the vaginal keratosis caused by estrogen stimulation.Liarozole (40 mg/kg; p.o.; 21 days) reduces tumor burden substantially.
CAS Number
115575-11-6
Product Name Alternative
R75251 dihydrochloride
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
ClC1=CC (C (C2=CC=C3NC=NC3=C2) N4C=CN=C4) =CC=C1
Molecular Formula
C17H13ClN4
Molecular Weight
308.76
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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