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AMG 511

CAT: 0013-GTR19156319-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156319-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks (Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively) . It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease.
CAS Number
1253573-53-3
Purity
>98% (HPLC)
Solubility
DMSO:33.33 mg/mL (64.40 mM; Need ultrasonic)
Smiles
C[C@H] (c (cc1-c2nc (N) nc (C) n2) cnc1Nc (cc1F) cnc1OC) N (CC1) CCN1S (C) (=O) =O
Molecular Formula
C22H28FN9O3S
Molecular Weight
517.58
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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