Products for Research Use Only
RegisterLogin

CFI-400945

CAT: 0013-GTR19156241-02Size: 500 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19156241-02Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4 (PLK4; Ki value of 0.26 nM) .
CAS Number
1338806-73-7
Field of Research
Immunology & Inflammation
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (187.04 mM; warmed with 50oC water bath) ; Ethanol:100 mg/mL (187.04 mM) ; Water:Insoluble
Smiles
C[C@@H]1CN (C[C@@H] (O1) C) CC2=CC=C (C=C2) /C=C/C3=NNC4=C3C=CC (=C4) [C@@H]5C[C@]56C7=C (C=CC (=C7) OC) NC6=O
Molecular Formula
C33H34N4O3
Molecular Weight
534.65
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

CFI-400945 free base

Ocifisertib is a polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon administration, ocifisertib selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle.

CAS Number1338806-73-7
PubChem CID58486178
IUPAC Name(2'S,3R)-2'-[3-[(E)-2-[4-[[(2S,6R)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5-methoxyspiro[1H-indole-3,1'-cyclopropane]-2-one
Molecular FormulaC33H34N4O3
Molecular Weight534.6
XLogP4.7
Topological Polar Surface Area79.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count40
Formal Charge0
Complexity942
SMILES
C[C@@H]1CN(C[C@@H](O1)C)CC2=CC=C(C=C2)/C=C/C3=NNC4=C3C=CC(=C4)[C@@H]5C[C@]56C7=C(C=CC(=C7)OC)NC6=O
InChI
InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1
InChIKey
DADASRPKWOGKCU-FVTQAUBDSA-N
Chemical Structure
2D Structure
2D structure of CFI-400945 free base
CAS: 1338806-73-7
CID: 58486178
Formula: C33H34N4O3
MW: 534.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight534.6
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass534.26309096
Monoisotopic Mass534.26309096
Topological Polar Surface Area79.5 Ų
Heavy Atom Count40
Formal Charge0
Complexity942
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19208455-01CFI-400936
GTR18236135-01CFI Antibody
GTR18189323-01CFI Antibody
GTR18058656-01CFI Antibody
GTR18173641CFI Antibody
GTR18173631CFI Antibody
GTR18160497-01CFI Antibody
GTR18160487-01CFI Antibody
GTR18063301-01CFI antibody
GTR17885008-01CFI Antibody

Alternative Products

CatalogName
B1287-25CFI-400945
A22256-100CFI-400945 100mg
A22256-50CFI-400945 50mg
A22256-25CFI-400945 25mg
A22256-10CFI-400945 10mg
A22256-5CFI-400945 5mg
A22256-1CFI-400945 1mg

Popular Products