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Elenbecestat

CAT: 0013-GTR19156186-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156186-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Elenbecestat is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease. (In Vitro) :Elenbecestat (E2609) is a potent BACE1 inhibitor with an IC50 of ~7 nmol/L in cell-based assay.Elenbecestat has been shown to reduce Ab production in the plasma, brain, and cerebrospinal fluid (CSF) of rodents. (In Vivo) :Elenbecestat (E2609; 0.3-30 mg/kg; p.o.) potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF of non-human primates.Elenbecestat displays the plasma half-life of 12-16 hours after once daily dosing.
CAS Number
1388651-30-6
Product Name Alternative
E2609
Purity
>98% (HPLC)
Solubility
DMSO:250 mg/mL (571.51 mM)
Smiles
C[C@H]1OC[C@]2 (c (cc (cc3) NC (c4ncc (C (F) F) nc4) =O) c3F) N=C (N) SC[C@H]12
Molecular Formula
C19H18F3N5O2S
Molecular Weight
437.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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