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Bractoppin

CAT: 0013-GTR19155871-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155871-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t) BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
CAS Number
2290527-07-8
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
O=C (N1CCN (CC2=CC=CC=C2F) CC1) C3=CC=C4NC (C5=CC=CC=C5) =NC4=C3
Molecular Formula
C25H23FN4O
Molecular Weight
414.47
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
BA3979-25Bractoppin
A22558-1Bractoppin 1mg
A22558-500Bractoppin 500mg
A22558-100Bractoppin 100mg
A22558-50Bractoppin 50mg
A22558-25Bractoppin 25mg
A22558-10Bractoppin 10mg
A22558-5Bractoppin 5mg
A22558-10mM-DBractoppin 10mM * 1mL in DMSO

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