PD 089828

CAT: 0013-GTR19155687-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19155687-02Size:5 mg

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Description

PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)

CAS Number

179343-17-0

Product Name Alternative

PD-089828 | PD089828

Purity

>98% (HPLC)

Solubility

DMSO:2.5 mM

Smiles

CC (C) (C) NC (=O) NC1=C (C=C2C=NC (=NC2=N1) N) C3=C (C=CC=C3Cl) Cl

Molecular Formula

C18H18Cl2N6O

Molecular Weight

405.28

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Chemical Information

1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea

CAS Number	179343-17-0
PubChem CID	5328112
IUPAC Name	1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
Molecular Formula	C18H18Cl2N6O
Molecular Weight	405.3
XLogP	3.7
Topological Polar Surface Area	106
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	27
Formal Charge	0
Complexity	520

SMILES

CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl

InChI

InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)

InChIKey

RRWSNCZYJCOEFX-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 179343-17-0

CID: 5328112

Formula: C18H18Cl2N6O

MW: 405.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	405.3
XLogP3	3.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	404.0919146
Monoisotopic Mass	404.0919146
Topological Polar Surface Area	106 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	520
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
462088	PD 089828
HY-112345-01	PD-089828
A22103-500	PD-089828 500mg
A22103-50	PD-089828 50mg
A22103-25	PD-089828 25mg
A22103-100	PD-089828 100mg
A22103-10	PD-089828 10mg
A22103-5	PD-089828 5mg
A22103-1	PD-089828 1mg

PD 089828

Chemical Information

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