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Iclaprim

CAT: 0013-GTR19155612-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155612-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Iclaprim is a novel specific bacterial Dihydrofolate inhibitor. It can inhibit the growth of S. aureus (MIC90: 0.06 μg/mL) . (In Vitro) :Iclaprim inhibits the growth of S. aureus (MRSA) with an MIC90 of 0.06 μg/mL.
CAS Number
192314-93-5
Product Name Alternative
AR-100
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:28 mg/mL (79 mM; Need ultrasonic and warming)
Smiles
COc1cc (Cc2c (N) nc (N) nc2) c (C=CC (C2CC2) O2) c2c1OC
Molecular Formula
C19H22N4O3
Molecular Weight
354.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Iclaprim

5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine is an aminopyrimidine that is 5-methylpyrimidine-2,4-diamine in which one of the hydrogens of the methyl group has been replaced by a 2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl group. It is a member of chromenes, an aminopyrimidine and a member of cyclopropanes.

CAS Number192314-93-5
PubChem CID213043
IUPAC Name5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine
Molecular FormulaC19H22N4O3
Molecular Weight354.4
XLogP2.5
Topological Polar Surface Area106
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity515
SMILES
COC1=C(C2=C(C=CC(O2)C3CC3)C(=C1)CC4=CN=C(N=C4N)N)OC
InChI
InChI=1S/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23)
InChIKey
HWJPWWYTGBZDEG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Iclaprim
CAS: 192314-93-5
CID: 213043
Formula: C19H22N4O3
MW: 354.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.4
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass354.16919058
Monoisotopic Mass354.16919058
Topological Polar Surface Area106 Ų
Heavy Atom Count26
Formal Charge0
Complexity515
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A20367-100Iclaprim 100mg
A20367-50Iclaprim 50mg
A20367-25Iclaprim 25mg

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