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Cenicriviroc

CAT: 0013-GTR19155532-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155532-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity. (In Vitro) :Cenicriviroc prevents human immunodeficiency virus type 1 (HIV-1) from cellular entry. Regarding the 4 R5 HIV-2 clinical isolates tested, effective concentration 50% EC50 for cenicriviroc are 0.03, 0.33, 0.45 and 0.98 nM. The dual-tropic and the X4-tropic HIV-2 strains are resistant to cenicriviroc with EC50 at >1000 nM, and MPI at 33% and 4%, respectively. (In Vivo) :Cenicriviroc (≥20 mg/kg/day) significantly reduces monocyte/macrophage recruitment in vivo. At these doses, cenicriviroc shows antifibrotic effects, with significant reductions in collagen deposition, and collagen type 1 protein and mRNA expression across the three animal models of fibrosis. In the NASH model, cenicriviroc significantly reduces the non-alcoholic fatty liver disease activity score. Cenicriviroc treatment has no notable effect on body or liver/kidney weight.
CAS Number
497223-25-3
Product Name Alternative
TAK-652 | TBR-652
Purity
>98% (HPLC)
Solubility
DMSO:120 mg/mL (172.19 mM)
Smiles
CCCCOCCOC1=CC=C (C=C1) C2=CC/3=C (C=C2) N (CCC/C (=C3) /C (=O) NC4=CC=C (C=C4) [S@@] (=O) CC5=CN=CN5CCC) CC (C) C
Molecular Formula
C42H52N4O4
Molecular Weight
696.94
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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