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Oxocarbazate

CAT: 0804-HY-139111Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139111Size:1 Each
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Description
Oxocarbazate is an inhibitor of human cathepsin L with the IC50 values of 6.9 nM (human Cathepsin L,0 h) 0.4 nM ((human Cathepsin L,4 h) and 5.07 μM (human cathepsin B), respectively. Oxocarbazate blockes both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into 293T cells[1].
CAS Number
1014405-03-8
UNSPSC
12352005
Target
Cathepsin; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/oxocarbazate.html
Smiles
O=C(N1C2=CC=CC=C2CCC1)COC(NNC([C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=CC=CC=C34)=O)=O
Molecular Formula
C28H33N5O6
Molecular Weight
535.59
References & Citations
[1]Shah PP, et al. A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. Mol Pharmacol. 2010;78 (2) :319-324.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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