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Blebbistatin

CAT: 0013-GTR19155064-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155064-02Size:500 mg
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Description
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing. Furthermore it preserves cell junctional integrity and barrier function.
CAS Number
674289-55-5
Product Name Alternative
(±) -Blebbistatin
Purity
>98% (HPLC)
Solubility
DMSO : 23 mg/mL (78.67 mM; Need ultrasonic)
Smiles
Cc (cc1) cc (C (C2 (CC3) O) =O) c1N=C2N3c1ccccc1
Molecular Formula
C18H16N2O2
Molecular Weight
292.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo(2,3-b)quinolin-4-one

Blebbistatin is a pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase activity of non-muscle myosin II. It has a role as an inhibitor. It is a tertiary alpha-hydroxy ketone, a tertiary alcohol, a cyclic ketone and a pyrroloquinoline.

CAS Number674289-55-5
PubChem CID3476986
IUPAC Name3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
Molecular FormulaC18H16N2O2
Molecular Weight292.3
XLogP2.4
Topological Polar Surface Area52.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count22
Formal Charge0
Complexity497
SMILES
CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O
InChI
InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3
InChIKey
LZAXPYOBKSJSEX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo(2,3-b)quinolin-4-one
CAS: 674289-55-5
CID: 3476986
Formula: C18H16N2O2
MW: 292.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight292.3
XLogP32.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass292.121177757
Monoisotopic Mass292.121177757
Topological Polar Surface Area52.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity497
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1387-S(-)-Blebbistatin
B6847-1(±)-Blebbistatin
T6038-01(-) -Blebbistatin
2407-5(+)-Blebbistatin
MBS3614304-01Blebbistatin
BML-EI315-0025Blebbistatin (+/-)
sc-203532D(±) -Blebbistatin
BUP09824-01(+) -Blebbistatin
FB18838-01(+/-) -Blebbistatin

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