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Arglabin

CAT: 0013-GTR19154905-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19154905-01Size:200 mg
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Description
Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects. (In Vitro) :The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene, a process that is believed to play a pivotal role in 20-30% of all human tumors. It actually inhibits the incorporation of farnesyl pyrophosphate into human H-ras proteins by the enzyme farnesyl transferase (FTase) . (In Vivo) :Arglabin reduces inflammation and plasma lipids, increases autophagy, and orients tissue macrophages into an anti-inflammatory phenotype in ApoE2.Ki mice fed a high-fat diet.
CAS Number
84692-91-1
Product Name Alternative
(+) -Arglabin
Purity
>98% (HPLC)
Solubility
DMSO:95 mg/mL (385.7 mM)
Smiles
C[C@]1 (CC[C@] (C2=C) ([H]) [C@@] (OC2=O) ([H]) [C@@]3 ([H]) C (C) =CC4) [C@]34O1
Molecular Formula
C15H18O3
Molecular Weight
246.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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