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MF-766

CAT: 0013-GTR19155534Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155534Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MF-766 (MF766) is a highly potent and selective EP (4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM) ; behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM) ; demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling.
CAS Number
1050656-06-8
Purity
>98%
Smiles
O=C (O) C1=CC=C (C2 (NC (C3=CC=CC4=C3N (CC5=CC=C (C (F) (F) F) C=C5) C=C4) =O) CC2) C=C1
Molecular Formula
C27H21F3N2O3
Molecular Weight
478.471
Notes
For research use only.

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