BGB283

CAT: 0013-GTR19155157-02Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19155157-02Size:100 mg

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Description

Lifirafenib (BGB-283) is a Novel potent and selective RAF Kinase and EGFR inhibitor.

CAS Number

1446090-77-2

Purity

>98%

Smiles

FC (F) (F) C (C=C1) =CC2=C1N=C (N2) [C@@H]3[C@H] ([C@@H]43) OC (C4=C5) =CC=C5OC6=CC=NC (N7) =C6CCC7=O

Molecular Formula

C25H17F3N4O3

Molecular Weight

478.43

Notes

For research use only.

Chemical Information

Lifirafenib

Lifirafenib is under investigation in clinical trial NCT03641586 (The Study of BGB-283 in Chinese Subjects With Local Advanced or Metastatic Malignant Solid Tumor).

CAS Number	1446090-77-2
PubChem CID	89670174
IUPAC Name	5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
Molecular Formula	C25H17F3N4O3
Molecular Weight	478.4
XLogP	3.7
Topological Polar Surface Area	89.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Heavy Atom Count	35
Formal Charge	0
Complexity	845

SMILES

C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)O[C@H]5[C@@H]4[C@@H]5C6=NC7=C(N6)C=C(C=C7)C(F)(F)F

InChI

InChI=1S/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)/t20-,21-,22-/m0/s1

InChIKey

NGFFVZQXSRKHBM-FKBYEOEOSA-N

Chemical Structure

2D Structure

CAS: 1446090-77-2

CID: 89670174

Formula: C25H17F3N4O3

MW: 478.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	478.4
XLogP3	3.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Exact Mass	478.12527490
Monoisotopic Mass	478.12527490
Topological Polar Surface Area	89.1 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	845
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

BGB283

Chemical Information

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