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PKZ18

CAT: 0013-GTR19154285Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19154285Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PKZ18 is a novel antibiotic that effectively suppresses bacterial growth, exhibiting MIC values ranging from 32 to 64 μg/mL against a broad spectrum of Gram-positive bacteria. Its mechanism involves the selective inhibition of glycyl-tRNA synthetase mRNA transcription and translation in vivo. PKZ18 specifically targets stem I specifier loops in Gram-positive bacteria, disrupting T-box-mediated transcriptional read-through of downstream genes. By interfering with codon-anticodon recognition, it blocks essential tRNA binding and demonstrates a high barrier to resistance development.
CAS Number
849658-87-3
Purity
>98%
Smiles
[C@]12 ([H]) C[C@] ([H]) (CC1) [C@@H] (C (NC1=NC (C3=CC=C (C (C) C) C=C3) =C (C) S1) =O) [C@H]2C (O) =O
Molecular Formula
C22H26N2O3S
Molecular Weight
398.518444538116
Notes
For research use only.

Alternative Products

CatalogName
HY-169810PKZ18

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