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XL177A

CAT: 0013-GTR19154218-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19154218-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XL177A is a potent USP7 inhibitor. XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome. Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells.
CAS Number
188719-92-8
Purity
>98%
Smiles
O ([H]) /N=C (/C ([H]) ([H]) C ([H]) ([H]) C ([H]) (C ([H]) ([H]) [H]) C ([H]) ([H]) [H]) \N ([H]) [H]
Molecular Formula
C6H14N2O
Molecular Weight
130.1882
Notes
For research use only.

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