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Glabrescione B

CAT: 0013-GTR19154189Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19154189Size:5 mg
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Description
Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction, inhibits Hh signaling by impairing Gli1 function; inhibits the growth of Hedgehog-dependent tumor cells in vitro and in vivo, inhibits Gli1-dependent growth of cerebellum-derived normal progenitors; inhibits the growth of Gli-dependent medulloblastoma and tumor-derived stem-like cells; inhibits the growth of Gli-dependent basal cell carcinoma in vitro and in vivo.
CAS Number
65893-94-9
Purity
>98%
Smiles
O=C1C (C2=CC=C (OC/C=C (C) /C) C (OC/C=C (C) /C) =C2) =COC3=CC (OC) =CC (OC) =C13
Molecular Formula
C27H30O6
Molecular Weight
450.52
Notes
For research use only.

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