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Cevidoplenib

CAT: 0013-GTR19154147-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19154147-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC50s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively.
CAS Number
1703788-21-9
Purity
>98%
Smiles
O=C (C1=CN (C) C2C=CC (=CC1=2) NC1N=CC=C (N=1) N1C=C (C (C) =N1) CN1C[C@@H] (CO1) O) C1CC1
Molecular Formula
C25H27N7O3
Molecular Weight
473.526984453201
Notes
For research use only.

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