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DLin-MC3-DMA

CAT: 0013-GTR19153918-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19153918-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Lin-MC3-DMA (MC3) is the most potent cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA.
CAS Number
1224606-06-7
Product Name Alternative
1224606-06-7, D-Lin-MC3-DMA, (6Z,9Z,28Z,31Z) -Heptatriaconta-6,9,28,31-tetraen-19-yl 4- (dimethylamino) butanoate
Field of Research
Immunology & Inflammation
Purity
>98%
Smiles
CCCCC/C=C\C/C=C\CCCCCCCCC (OC (=O) CCCN (C) C) CCCCCCCC/C=C\C/C=C\CCCCC
Molecular Formula
C43H79NO2
Molecular Weight
641.61
References & Citations
Ye Zeng 1, Mariona Estapé Senti 2, M Clara I Labonia 3, Panagiota Papadopoulou 1, Maike A D Brans 3, Inge Dokter 3 4, Marcel H Fens 5, Alain van Mil 3 4, Joost P G Sluijter 3 4, Raymond M Schiffelers 2, Pieter Vader 2 3, Alexander Kros 1 Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration ACS Nano, 17 (23), 23466–23477 (2023), Gangyin Zhao 1 2, Ye Zeng 3, Wanli Cheng 4, Sofia Karkampouna 4 5, Panagiota Papadopoulou 3, Bochuan Hu 3, Shuya Zang 3, Emma Wezenberg 3, Gabriel Forn-Cuní 1, Bruno Lopes-Bastos 1, Marianna Kruithof-de Julio 5, Alexander Kros 3, B Ewa Snaar-Jagalska 1 Peptide-Modified Lipid Nanoparticles Boost the Antitumor Efficacy of RNA Therapeutics ACS Nano, (2025), Hend Mohamed Abdel-Bar et al. Optimizing Exosome Lipid Hybrid Nanoparticles for Enhanced siRNA Delivery and Improved Therapeutic Anticancer Efficacy In Vivo ACS Nano, 19 (50), 42658-42674 (2025)
Pubmed id
37982378, 40176316, 41378821
Storage Conditions
Pure form: -20°C/3 years,4°C/2 years; In solvent: -20°C/1 month
Notes
For research use only.
Applications Notes
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

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