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IWP-2-V2

CAT: 0013-GTR19153670-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19153670-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. 1, 2, 3 Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 (Item No. 13951) is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential For the signaling ability and secretion of Wnt proteins.4 IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound.4 It has been used to determine which structural features of IWP-2 are essential For impairing Wnt/β-catenin pathway activity.4 For the detailed information of IWP-2-V2, the solubility of IWP-2-V2 in water, the solubility of IWP-2-V2 in DMSO, the solubility of IWP-2-V2 in PBS buffer, the animal experiment (test) of IWP-2-V2, the cell expriment (test) of IWP-2-V2, the in vivo, in vitro and clinical trial test of IWP-2-V2, the EC50, IC50, and Affinity of IWP-2-V2.
CAS Number
877618-79-6
Purity
>98%
Smiles
CC1=CC2=C (C=C1) N=C (S2) NC (=O) CSC3=NC4=C (C (=O) N3CC5=CC=CC=C5) SCC4
Molecular Formula
C23H20N4O2S
Molecular Weight
480.6
Notes
For research use only.

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