Suvorexant

Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.Suvorexant is an analytical reference standard categorized as a diazepane sedative.Formulations containing suvorexant show abuse potential similar to zolpidem in recreational polydrug users with a history of sedative and psychedelic drug use.2 Suvorexant is regulated as a Schedule IV compound in the United States. This product is intended for use in analytical forensic applications.

1030377-33-3

(R) - (4- (5-Chlorobenzo[d]oxazol-2-yl) -7-methyl-1,4-diazepan-1-yl) (5-methyl-2- (2H-1,2,3-triazol-2-yl) phenyl) methanone; Suvorexant MK4305; MK 4305; MK-4305; Suvorexant (MK-4305) ; [ (7R) -4- (5-chloro-1,3-benzoxazol-2-yl) -7-methyl-1,4-diazepan-1-yl]-[5-methyl-2- (triazol-2-yl) phenyl]methanone;5-Chloro-2-[ (5R) -5-methyl-4-[5-methyl-2- (2H-1,2,3-triazol-2-yl) benzoyl]-1,4-diazepan-1-yl]-1,3-benzoxazole; Suvorexant; [ (7R) -4- (5-Chloro-1,3-benzoxazol-2-yl) -7-methyl-1,4-diazepan-1-yl][5-methyl-2- (2H-1,2,3-triazol-2-yl) phenyl]methanone; [ (R) -4- (5-chlorobenzooxazol-2-yl) -7-methyl-[1,4]diazepan-1-yl] (5-methy;5-chloro-2-{ (5R) -5-methyl-4-[5-methyl-2- (2H-1,2,3-triazol-2-yl) benzoyl]-1,4-diazepan-1-yl}-1,3-benzoxazole; Belsomra?; DORA-analogue; EOS-61934; SUVOREXABT; MK-4305 (Suvorexant) ; Synonyms Suvorexant; Suvorexant (with 4 ints.) ; BELSOMRA; MK4305;081L192FO9; C23H23ClN6O2; ((7R) -4- (5-Chloro-1,3-benzoxazol-2-yl) -7-methyl-1,4-diazepan-1-yl) (5-methyl-2- (2H-1,2,3-triazol-2-yl) phenyl) methanone; (R) - (4- (5-chlo

Pharmacology & Drug Discovery

ClC1C ([H]) =C ([H]) C2=C (C=1[H]) N=C (N1C ([H]) ([H]) C ([H]) ([H]) N (C (C3C ([H]) =C (C ([H]) ([H]) [H]) C ([H]) =C ([H]) C=3N3N=C ([H]) C ([H]) =N3) =O) [C@] ([H]) (C ([H]) ([H]) [H]) C ([H]) ([H]) C1 ([H]) [H]) O2

C23H23CLN6O2

450.9207

Carlos Carrera-Cañas 1, Isabel de Andrés 1, Marta Callejo 1, Miguel Garzón 2 Hypocretin/orexin peptide release occurs mostly extrasynaptically, is self-controlled, and specifically enhanced in female rats Exp Neurol, (2025), Hiroki Endo et al. Dexamethasone induces sleep disruption in male mice and is associated with hyperactivation of orexin neurons Psychopharmacology (Berl) ., (2026), Gun Young Yoon et al. Disruption of the hypothalamic orexin system links SARS-CoV-2 infection to persistent cortical neuronal pathology bioRxiv, (2026)

40846248, 41984203

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO