Bestatin

• Description :

  Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N) /APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects[1][2].

• Product Name Alternative :

  Ubenimex

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Aminopeptidase; Antibiotic; Bacterial

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/Bestatin.html

• Purity :

  99.98

• Solubility :

  DMSO : 8.33 mg/mL (ultrasonic)

• Smiles :

  CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O

• Molecular Formula :

  C16H24N2O4

• Molecular Weight :

  308.37

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Hossain A, et al. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 Aug;149:100-6|[2]Qian X, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2016 May-Jun;23 (3) :e680-9.|[3]Lis M, et al. The effects of bestatin on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice. Immunopharmacol Immunotoxicol. 2013 Feb;35 (1) :133-8|[4]Poloz Y, et al. Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum. Eukaryot Cell. 2012 Apr;11 (4) :545-57

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  CD13

• CAS Number :

  [58970-76-6]