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HS-173

CAT: 0013-GTR19160757-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160757-01Size:200 mg
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Description
HS-173 is a potent PI3Kα inhibitor with potential anticancer activity. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G (2) /M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients.
CAS Number
1276110-06-5
Product Name Alternative
HS173 | HS 173 | HS-173
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 26 mg/mL. 61.54 mM
Smiles
S (=O) (=O) (Nc1cc (cnc1) c1ccc2n (c1) c (cn2) C (=O) OCC) c1ccccc1
Molecular Formula
C21H18N4O4S
Molecular Weight
422.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethyl 6- (5- (phenylsulfonamido) pyridin-3-yl) imidazo[1,2-a]pyridine-3-carboxylate

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