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Pritelivir

CAT: 0013-GTR19160344-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160344-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pritelivir (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM) . (In Vivo) :Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase-primase enzyme complex.Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis.Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS.
CAS Number
348086-71-5
Product Name Alternative
BAY 57-1293 | AIC316
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 33 mg/mL; 81.99 mM
Smiles
Cc1c (sc (n1) N (C) C (=O) Cc1ccc (cc1) c1ccccn1) S (=O) (=O) N
Molecular Formula
C18H18N4O3S2
Molecular Weight
402.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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HY-15303ARPritelivir (mesylate) (Standard)
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