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K03861

CAT: 0013-GTR19160221-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160221-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AUZ454 is a potent and selective Type II FLT3 inhibitor. AUZ454 is able to override drug resistance that less potent "type I" inhibitors and "type II" first-generation FLT3 inhibitors cannot. Constitutively activated mutant FLT3 has emerged as a promising target for therapy for the subpopulation of acute myeloid leukemia (AML) patients who harbor it. The small molecule inhibitor, PKC412, targets mutant FLT3 and is currently in late-stage clinical trials. However, the identification of PKC412-resistant leukemic blast cells in the bone marrow of AML patients has propelled the development of novel and structurally distinct FLT3 inhibitors that have the potential to override drug resistance and more efficiently prevent disease progression or recurrence.
CAS Number
853299-07-7
Product Name Alternative
AUZ454 | AUZ 454 | AUZ-454 | K03861
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 33 mg/mL; 65.80 mM
Smiles
CN1CCN (CC2=CC=C (NC (=O) NC3=CC=C (OC4=NC (N) =NC=C4) C=C3) C=C2C (F) (F) F) CC1
Molecular Formula
C24H26F3N7O2
Molecular Weight
501.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (4- ((2-aminopyrimidin-4-yl) oxy) phenyl) -3- (4- ((4-methylpiperazin-1-yl) methyl) -3- (trifluoromethyl) phenyl) urea

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Alternative Products

CatalogName
B6042-5K03861
A15889-25K03861 25mg
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A15889-200K03861 200mg
A15889-100K03861 100mg
A15889-50K03861 50mg
A15889-10K03861 10mg
A15889-5K03861 5mg
A15889-10mM-DK03861 10mM * 1mL in DMSO

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