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Donepezil

CAT: 0013-GTR19159764-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159764-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Donepezil is a medication used in the palliative treatment of Alzheimer's disease. Donepezil is used to improve cognition and behavior of people with Alzheimer's, but does not slow the progression of or cure the disease. (In Vitro) :Donepezil (E2020 free base) inhibits the carbachol-stimulated increase in intracellular Ca2+ concentration in human SHSY5Y neuroblastoma cells in a concentration dependent manner, indicating that Donepezil have muscarinic antagonist activity. Intraperitoneal administration of Donepezil in rats produces a dose dependent increase in salivation and tremor, which are overt cholinergic behavioural signs, with an ED50 of 6 μmol/kg. Donepezil is found to be somewhat less potent with a ED50 of 50 μmol/kg following oral administration.A recent study shows that Donepezil can protect human umbilical vein endothelial cells (HUVECs) against H2O2-induced cell injury. This may be useful as a potential therapy for oxidative stress in cardiovascular and cerebrovascular diseases.
CAS Number
120014-06-4
Product Name Alternative
HSDB 7743 | HSDB7743 | HSDB-7743 | Donepezil
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : 33.33 mg/mL 87.83 mM
Smiles
COc1cc2CC (CC3CCN (Cc4ccccc4) CC3) C (=O) c2cc1OC
Molecular Formula
C24H29NO3
Molecular Weight
379.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((1-benzylpiperidin-4-yl) methyl) -5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Alternative Products

CatalogName
sc-211231Dehydrodeoxy Donepezil (Donepezil Impurity)
sc-218104Dehydro Donepezil (Donepezil Impurity)
M17876-01Donepezil
447654(-) -Donepezil
574677(+)-Donepezil
T70697-01(+) -Donepezil

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