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Licochalcone D

CAT: 0013-GTR19159629-07Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159629-07Size:50 mg
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Description
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotective potential against myocardial ischemia/reperfusion injury in langendorff-perfused rat hearts. Licochalcone D has anti-inflammatory activity, it shows suppression ability of nitric oxide (NO) production. Licochalcone D has anti-allergic activity, it suppresses degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.
CAS Number
144506-15-0
Product Name Alternative
Licochalcone D | Licochalcone-D
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (352.71 mM)
Smiles
COc1c (O) c (O) ccc1\C=C\C (=O) c1ccc (O) c (CC=C (C) C) c1
Molecular Formula
C21H22O5
Molecular Weight
354.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -3- (3,4-Dihydroxy-2-methoxyphenyl) -1-[4-hydroxy-3- (3-methylbut-2-enyl) phenyl]prop-2-en-1-one

Chemical Information

Licochalcone D

licochalcone d has been reported in Glycyrrhiza inflata with data available.

CAS Number144506-15-0
PubChem CID10473311
IUPAC Name(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
Molecular FormulaC21H22O5
Molecular Weight354.4
XLogP4.5
Topological Polar Surface Area87
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity522
SMILES
CC(=CCC1=C(C=CC(=C1)C(=O)/C=C/C2=C(C(=C(C=C2)O)O)OC)O)C
InChI
InChI=1S/C21H22O5/c1-13(2)4-5-15-12-16(8-10-18(15)23)17(22)9-6-14-7-11-19(24)20(25)21(14)26-3/h4,6-12,23-25H,5H2,1-3H3/b9-6+
InChIKey
RETRVWFVEFCGOK-RMKNXTFCSA-N
Chemical Structure
2D Structure
2D structure of Licochalcone D
CAS: 144506-15-0
CID: 10473311
Formula: C21H22O5
MW: 354.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.4
XLogP34.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass354.14672380
Monoisotopic Mass354.14672380
Topological Polar Surface Area87 Ų
Heavy Atom Count26
Formal Charge0
Complexity522
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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