Ginsenoside Rh2

Ginsenoside Rh2 is an aldose reductase inhibitor found in Panax. It also decreases ROS levels in keratinocytes, lowers levels of amyloid-β in Alzheimer's disease models, induces β-cell proliferation, inhibits osteoclastogenesis by suppressing RANKL-induced osteoclast differentiation. (In Vitro) :Ginsenoside Rh2 induces the activation of two initiator caspases, caspase-8 and caspase-9 in human cancer cells. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner and is therefore a promising candidate for anti-tumor drug development. Ginsenoside Rh2 triggers p53-dependent Fas expression and consequent activation of caspase-8 and p53-independent caspase-9-mediated intrinsic pathway to cause cancer cell death.The cytotoxic activity of Ginsenoside Rh2 in the human tumor cell lines HeLa, SK-HEP-1, SW480, and PC-3 is assessed by MTT. The cell viability of HeLa cells is remarkably inhibited by Ginsenoside Rh2, with an IC50 value of 2.52 μg/mL, whereas SK-HEP-1 and SW480 cells are less sensitive to Ginsenoside Rh2, with IC50 values of 3.15 μg/mL and 4.06 μg/mL, respectively. PC-3 cells are the least vulnerable to Ginsenoside Rh2, with an IC50 value of 7.85 μg/mL, 3-fold higher than HeLa cells. (In Vivo) :A total of 15 days following B16-F10 cell injection, tumor sizes from the 3 tumor bearing groups are measured. The tumor sizes in the G-L group and G-H group (G-L and G-H refer to a low or high dose of ginsenoside Rh2 injection) are reduced compared with the tumor group (P<0.05) . The survival analysis reveals that the Ginsenoside Rh2 treated groups survive longer than the untreated tumor group and the effect is dose-dependent (P<0.05) .

78214-33-2

Ginsenoside Rh2 | HY-N0605 | HY N0605

Immunology & Inflammation

>98% (HPLC)

DMSO : ≥ 300 mg/mL; 481.64 mM

O[C@H]1[C@@H] (O[C@@H] ([C@H] ([C@@H]1O) O) CO) O[C@@H]1C ([C@H]2[C@@] ([C@@H]3[C@] ([C@]4 ([C@H] ([C@@H] (C3) O) [C@@H] ([C@@] (O) (CCC=C (C) C) C) CC4) C) (CC2) C) (CC1) C) (C) C

C36H62O8

622.87

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.