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PKM2 inhibitor

CAT: 0013-GTR19159245-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159245-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDK4882, also known as PKM2 inhibitor or compound 3k, is a PKM2 inhibitor. MDK4882 was first described in Eur J Med Chem. 2017;138:343-352. Currently there is no formal name. We temporarily name it MDK4882 for the convenience of communication, in which the last 4 digit of CAS# is used. MDK4882 displayed more potent PKM2 inhibitory activity than the reported optimal PKM2 inhibitor shikonin. MDK4882 also showed nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18 to 1.56 μM. MDK4882 exhibited more cytotoxicity on cancer cells than normal cells.
CAS Number
94164-88-2
Product Name Alternative
PKM2 inhibitor | MDK4882
Field of Research
Metabolism Research; Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : 5.56 mg/mL 16.09 mM; H2O : < 0.1 mg/mL
Smiles
CC1=C (C (=O) c2ccccc2C1=O) CSC (=S) N1CCCCC1
Molecular Formula
C18H19NO2S2
Molecular Weight
345.48
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl) methyl piperidine-1-carbodithioate

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