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Radiprodil

CAT: 0013-GTR19158208-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158208-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP) . (In Vitro) :Preincubation with Radiprodil (10 nM) restores long-term potentiation (LTP) in the presence of Aβ1-42, 3NTyr10-Aβ and Aβ1-40, but not AβpE3.As for LTP, Radiprodil (10 nM) reverses the synaptic toxicity of 3NTyr-AβAβ1-40 and Aβ1-42 but not that AβpE3-42. (In Vivo) :Radiprodil could block NMDA currents in Mg2+ insensitive variants, with potencies similar to those obtained without Mg2+.Radiprodil's potency is higher at pH 7.0 than at pH 7.6, suggesting that radiprodil may retain its ability to block glutamate-induced NMDA currents even under acidic conditions that manifest under long term seizures.
CAS Number
496054-87-6
Product Name Alternative
RGH-896
Purity
>98% (HPLC)
Solubility
DMSO: 220 mg/mL (553.6 mM)
Smiles
Fc1ccc (CC2CCN (CC2) C (=O) C (=O) Nc2ccc3[nH]c (=O) oc3c2) cc1
Molecular Formula
C21H20FN3O4
Molecular Weight
397.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
BA6733-50Radiprodil
A21193-100Radiprodil 100mg
A21193-50Radiprodil 50mg
A21193-2Radiprodil 2mg
HY-14777R-01Radiprodil (Standard)
A21193-25Radiprodil 25mg
A21193-5Radiprodil 5mg
A21193-10Radiprodil 10mg
A21193-1Radiprodil 1mg
S6644-5mgRadiprodil (RGH-896)

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