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GMQ hydrochloride

CAT: 0013-GTR19157679-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157679-01Size:200 mg
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Description
GMQ hydrochloride is a potent and selective acid-sensing ion channel (ASIC) modulator. It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current.Addition of GMQ to pituitary GH3 cells raised the amplitude of Ca2+-activated K+ currents (IK (Ca) ), which was reversed by verruculogen or PF1022A, but not by TRAM-39. Under inside-out current recordings, addition of GMQ into bath enhanced the probability of large-conductance Ca2+-activated K+ (BKCa) channels with an EC50 value of 0.95 M. The activation curve of BKCa channels during exposure to GMQ shifted to a lower depolarized potential, with no change in the gating charge of the curve; however, there was a reduction of free energy for channel activation in its presence. As cells were exposed to GMQ, the amplitude of ion currents were suppressed, including delayed rectifying K+ current, voltage-gated Na+ and L-type Ca2+ currents. In Rolf B1.T olfactory sensory neuron, addition of GMQ was able to induce inward current and to suppress peak INa.
CAS Number
5361-15-9
Product Name Alternative
NSC 403387 hydrochloride
Purity
>98% (HPLC)
Solubility
In Vitro: H2O : 3.33 mg/mL (14.01 mM)
Smiles
CC1=NC (NC (N) =N) =NC2=C1C=CC=C2.Cl
Molecular Formula
C10H12ClN5
Molecular Weight
237.69
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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