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RBN-2397

CAT: 0013-GTR19157073-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157073-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RBN-2397 (0.0001-100 μM; 24 hours) inhibits cells proliferation with an IC50 value of 20 nM in NCI-H1373 lung cancer cells.RBN-2397 (0.4 nM-1 μM; 24 hours) shows a restoration of type I IFN response by an increase in STAT1 phosphorylation as a dose-dependent manner in NCI-H1373 human lung cancer cells.RBN-2397 (0.0001-1 μM; 24 hours) inhibits cell MARylation in a cell biochemial assay with an EC50 value of 1 nM. (In Vitro) :RBN-2397 (0.0001-100 μM; 24 hours) inhibits cells proliferation with an IC50 value of 20 nM in NCI-H1373 lung cancer cells.RBN-2397 (0.4 nM-1 μM; 24 hours) shows a restoration of type I IFN response by an increase in STAT1 phosphorylation as a dose-dependent manner in NCI-H1373 human lung cancer cells.RBN-2397 (0.0001-1 μM; 24 hours) inhibits cell MARylation in a cell biochemial assay with an EC50 value of 1 nM. (In Vivo) :RBN-2397 (oral administration; 3-100 mg/kg; once daily; 24-32 days) induces tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses in CT26 tumor-bearing BALB/c mice.RBN-2397 (oral administration; 3-100 mg/kg; once daily; 32 days) causes complete regressions at the dose 100 mg/kg and exerts a dose-dependent effects on tumor growth at dose levels of ≥30 mg/kg.The half-life (t1/2) of RBN-2397 in vivo is 325 mins.
CAS Number
2381037-82-5
Purity
>98% (HPLC)
Solubility
DMSO : 250 mg/mL (477.62 mM; Need ultrasonic)
Smiles
O=C1C (C (F) (F) F) =C (N[C@@H] (C) COCCC (N2CCN (C3=NC=C (C (F) (F) F) C=N3) CC2) =O) C=NN1
Molecular Formula
C??H??F?N?O?
Molecular Weight
523.43
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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