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CAY10404

CAT: 0013-GTR19157037-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157037-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells, with analgesic, anti-inflammatory and anti-cancer activities.Treatment with CAY10404 in the range of 10-100 microM caused dose-dependent growth inhibition, with an average 50% inhibitory concentration (IC (50) ) of 60-100 micromol/L, depending on the cell line. Western blot analysis of CAY10404-treated cells showed cleavage of poly (ADP-ribose) polymerase (PARP) and procaspase-3, signifying caspase activity and apoptotic cell death. CAY10404 treatment inhibited the phosphorylation of Akt, glycogen synthase kinase-3beta and extracellular signal-regulated kinases 1/2 in H460 and H358 cells.
CAS Number
340267-36-9
Product Name Alternative
3- (4-METHYLSULPHONYLPHENYL) -4-PHENYL-5-T
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (272.23 mM)
Smiles
CS (=O) (=O) c1ccc (cc1) -c1noc (c1-c1ccccc1) C (F) (F) F
Molecular Formula
C17H12F3NO3S
Molecular Weight
367.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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Alternative Products

CatalogName
A4626-5CAY10404
A22525-200CAY10404 200mg
A22525-100CAY10404 100mg
A22525-25CAY10404 25mg
A22525-50CAY10404 50mg
A22525-2CAY10404 2mg
A22525-10CAY10404 10mg
HY-121537R-01CAY10404 (Standard)
A22525-5CAY10404 5mg
A22525-10mM-DCAY10404 10mM * 1mL in DMSO

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