Taccalonolide A

CAT: 0013-GTR19156629-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19156629-01Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects, with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.

CAS Number

108885-68-3

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 100 mg/mL (142.30 mM)

Smiles

C[C@@]12[C@] ([C@@H] (OC (C) =O) [C@]3 ([H]) [C@]2 ([H]) [C@@H] (C=C (O4) [C@@]3 ([C@] (O) (C4=O) C) C) C) ([H]) [C@@] ([C@H]5O) ([H]) [C@] ([C@]6 ([C@H] ([C@@H] (O7) [C@@H]7C[C@]6 ([H]) C5=O) OC (C) =O) C) ([H]) [C@H] (OC (C) =O) [C@@H]1OC (C) =O

Molecular Formula

C36H46O14

Molecular Weight

702.74

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Alternative Products

Catalog	Name
M22824-01	Taccalonolide A
AB2829	Taccalonolide B
MBS5760963	Taccalonolide AJ
HY-N7669	Taccalonolide C
TN8250-01	Taccalonolide Q
HY-N11067-01	Taccalonolide E

Taccalonolide A

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