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Kurarinone

CAT: 0013-GTR19156593-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156593-01Size:1 g
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Description
Kurarinone, a flavanoid derived from shrub Sophora flavescens, Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4 (+) T-cell differentiation and the overall immune response.Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. METHODS AND RESULTS:Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC (50) values of 4.6 and 1.66 microM, respectively. Furthermore, Kurarinone was found to have potent cytotoxic activity (IC (50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay.
CAS Number
34981-26-5
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (114.02 mM)
Smiles
O=C1C[C@@H] (C2=CC=C (O) C=C2O) OC3=C (C[C@H] (C (C) =C) C/C=C (C) \C) C (O) =CC (OC) =C13
Molecular Formula
C26H30O6
Molecular Weight
438.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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