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Upamostat

CAT: 0013-GTR19155395-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155395-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor. (In Vitro) :Upamostat is the urokinase plasminogen activator (uPA) inhibitor. Upamostat is the oral pro-drug of the active metabolite WX-UK1, a novel uPA inhibitor. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, which plays a major role in tumor invasion and metastasis. Upamostat is the orally available amidoxime- (i.e. hydroxyamidine-) prodrug of the pharmacologically active form, WX-UK1. (In Vivo) :The validated method is used to evaluate the pharmacokinetics of Upamostat (Mesupron) in rats. The mean plasma concentrations of Upamostat after a single intravenous injection of 2 mg/kg in five rats are measured. The substance decays in a mono-phasic pattern with a terminal half-life of 0.5 h; its volume of distribution is 2.0 L/kg, and clearance is about 2.7 L/h/kg.
CAS Number
590368-25-5
Product Name Alternative
WX-671
Purity
>98% (HPLC)
Solubility
DMSO:250 mg/mL (396.95 mM)
Smiles
CCOC (=O) N1CCN (CC1) C (=O) [C@H] (CC2=CC (=CC=C2) /C (=N/O) /N) NS (=O) (=O) C3=C (C=C (C=C3C (C) C) C (C) C) C (C) C
Molecular Formula
C32H47N5O6S
Molecular Weight
629.81
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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