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Larazotide acetate

CAT: 0013-GTR19154839-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19154839-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state. (In Vitro) :Larazotide acetate (1-100 μM; 5 d) affects Vero cell growth.Larazotide acetate (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively.Larazotide acetate (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells.Larazotide acetate (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells. (In Vivo) :Larazotide acetate (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice.
CAS Number
881851-50-9
Purity
>98% (HPLC)
Solubility
H2O:16.67 mg/mL (21.21 mM; Need ultrasonic) ; DMSO:3.2 mg/mL (4.07 mM; Need ultrasonic and warming)
Smiles
O=C ([C@H] (C (C) C) NC ([C@H] (CC (C) C) NC ([C@H] (C (C) C) NC (CNC (CN) =O) =O) =O) =O) N[C@@H] (CCC (N) =O) C (N1[C@@H] (CCC1) C (NCC (O) =O) =O) =O.CC (O) =O
Molecular Formula
C34H59N9O12
Molecular Weight
785.89
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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