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Icotrokinra acetate

CAT: 0013-GTR19150474-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19150474-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Icotrokinra (JNJ-77242113) acetate is a potent oral selective antagonist of the IL-23 receptor. It inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (PBMC) with an IC50 of 5.6 pM and reduces IFN-γ production in natural killer (NK) cells induced by IL-23, with an IC50 of 18.4 pM. Icotrokinra acetate demonstrates anti-inflammatory properties in a TNBS-induced rat colitis model and is applicable to research on psoriasis, psoriatic arthritis, and inflammatory bowel diseases.
Notes
For research use only.

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