Treprostinil

CAT: 0804-HY-100441-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100441-01Size:2 mg
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Description
Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
CAS Number
[81846-19-7]
Product Name Alternative
UT-15
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Treprostinil.html
Purity
99.98
Solubility
DMSO : ≥ 125 mg/mL
Smiles
OC(COC1=CC=CC2=C1C[C@](C[C@@H](O)[C@@H]3CC[C@@H](O)CCCCC)([H])[C@]3([H])C2)=O
Molecular Formula
C23H34O5
Molecular Weight
390.51
Precautions
H302, H312, H332
References & Citations
[1]Whittle BJ, et al. Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem Pharmacol. 2012 Jul 1;84 (1) :68-75.|[2]Ferrantino M, et al. Inhaled treprostinil sodium for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2011 Nov;12 (16) :2583-93.|[3]Ghonem N, et al. Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov;11 (11) :2508-16.|[4]Smadja DM, et al. Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells. Thromb Haemost. 2015 Oct;114 (4) :735-47.|[5]Kazemi Z, et al. Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation. Mol Pharmacol. 2016 Jun;89 (6) :630-44.|[6]Nikam VS, et al. Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension. Eur Respir J. 2010 Dec;36 (6) :1302-14.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
DP; EP; FP; IP; TXA2/TP

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