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MMV390048

CAT: 0804-HY-106005-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106005-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM) . MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].
CAS Number
1314883-11-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Parasite; PI4K
Type
Reference compound
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mmv390048.html
Purity
98.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=C(C2=CC=C(S(=O)(C)=O)C=C2)C=C1C3=CC=C(C(F)(F)F)N=C3
Molecular Formula
C18H14F3N3O2S
Molecular Weight
393.38
Precautions
H302, H315, H319
References & Citations
[1]Paquet T, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9 (387) . pii: eaad9735.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Plasmodium

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MBS387914-01MMV390048
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A13566-50MMV390048 50mg
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A13566-25MMV390048 25mg
A13566-10MMV390048 10mg
A13566-5MMV390048 5mg
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