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VU6016235

CAT: 0804-HY-169178Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169178Size:1 Each
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Description
VU6016235 is a highly selective, orally available, positive allosteric modulator of the M4 mAChR with in vivo inhibitory potency in animal models of psychosis.[1].
CAS Number
2344787-70-6
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu6016235.html
Smiles
CC1=NC2=C(C3=C(S2)C(NCC4=CC=C(C=C4)C(C)(O)C)=NC=C3)C(C)=N1
Molecular Formula
C21H22N4OS
Molecular Weight
378.49
References & Citations
[1]Engers JL, et al. Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) . ACS Chem Neurosci. 2024 Sep 24;15 (20) :3744–54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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