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Sevasemten

CAT: 0804-HY-148799-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148799-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sevasemten is an orally active, selective allosteric inhibitor of skeletal muscle myosin that protects skeletal muscle from contraction-induced injury. Sevasemten decreases muscle damage biomarkers and fibrosis while increasing muscle strength and activity in in Duchenne muscular dystrophy disease models[1][2][3][4].
CAS Number
2417395-15-2
Product Name Alternative
EDG-5506
UNSPSC
12352005
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sevasemten.html
Purity
99.32
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1C=CC(C2=CN=C(OCC(F)(F)F)N=C2)=NN1CC3=CC(F)=CN=C3
Molecular Formula
C16H11F4N5O2
Molecular Weight
381.28
References & Citations
[1]Russell Alan, et al. Preparation of substituted pyridazinones for use in the treatment of neuromuscular diseases: World Intellectual Property Organization, WO2021231615. 2021-11-18.|[2]WHO Drug Information-World Health Organization (WHO) .|[3]Donovan J, et al. 351P Sevasemten, a fast myosin inhibitor, in adults with Becker muscular dystrophy results in reduced muscle damage biomarkers and functional stabilization[J]. Neuromuscular Disorders, 2024, 43: 104441.682.|[4]Russell AJ, et al., Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy. J Clin Invest. 2023 May 15;133 (10) :e153837.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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CatalogName
C15117-5mgSevasemten

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